Preoperative radiation may improve antitumor immune response in most common form of breast cancer​Preoperative radiation may improve antitumor immune response in most common form of breast cancer 

Preoperative radiation improved T-cell infiltration (TCI) in patients with hormone receptor (HR)-positive, HER2-negative breast cancer when administered in combination with pembrolizumab (Keytruda) and chemotherapy and led to improved treatment responses prior to surgery, according to the results of a Phase II P-RAD clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9–12, 2025.

A multimodal AI model may improve recurrence risk stratification in early breast cancer​A multimodal AI model may improve recurrence risk stratification in early breast cancer 

An artificial intelligence (AI) model created by integrating clinical, molecular, and histopathological data significantly improved recurrence risk stratification in hormone receptor (HR)-positive, HER2-negative breast cancer, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9–12, 2025.