Popular GLP-1 weight-loss drugs linked to lower risks of addiction and overdosePopular GLP-1 weight-loss drugs linked to lower risks of addiction and overdose

A massive study of more than 600,000 U.S. veterans suggests that popular GLP-1 drugs such as semaglutide may do far more than help with diabetes and weight loss—they could also fight addiction itself. Researchers found that people taking these medications were less likely to develop substance use disorders involving alcohol, nicotine, cannabis, cocaine, opioids, and Read More
This new diabetes pill burns fat without the downsides of OzempicThis new diabetes pill burns fat without the downsides of Ozempic

Scientists have developed an experimental diabetes and obesity pill that works in a completely different way from drugs like Ozempic. Rather than reducing hunger, it activates metabolism in skeletal muscle, helping lower blood sugar and increase fat burning while preserving muscle mass. Early clinical results suggest the treatment is safe and well tolerated. Scientists have Read More
STAT+: Pharmalittle: We’re reading about GLP-1 drugs and knees, FDA cell and gene therapy guidance, and moreSTAT+: Pharmalittle: We’re reading about GLP-1 drugs and knees, FDA cell and gene therapy guidance, and more

Good morning, everyone, and welcome to the middle of the week. Congratulations on making it this far, and remember there are only a few more days until the weekend arrives. So keep plugging away. After all, what are the alternatives? While you ponder the possibilities, we invite you to join us for a delightful cup Read More
Popular GLP-1 drug may slow down biological aging, analysis indicatesPopular GLP-1 drug may slow down biological aging, analysis indicates

Glucagon-like peptide-1 (GLP-1) receptor agonist medications have gained widespread attention for effectively treating obesity, lowering blood sugar and decreasing the risk of cardiovascular disease. Some researchers have proposed that these drugs may also influence the biology of aging, but direct evidence in humans has remained limited. Glucagon-like peptide-1 (GLP-1) receptor agonist medications have gained widespread Read More
GLP-1 agonists linked to significantly lower long-term risk of knee replacementGLP-1 agonists linked to significantly lower long-term risk of knee replacement

GLP-1 receptor agonist drugs, used for the treatment of diabetes—and more recently, weight loss—are associated with a significantly lower long-term risk of knee replacement surgery as a result of osteoarthritis, finds an analysis of medical records data, published in the open-access journal Regional Anesthesia & Pain Medicine. GLP-1 receptor agonist drugs, used for the treatment Read More
GLP-1 Drugs Cut Need for Knee ReplacementGLP-1 Drugs Cut Need for Knee Replacement

(MedPage Today) — People with knee osteoarthritis (OA) who used GLP-1 receptor agonists were less likely to undergo knee replacement surgery, an analysis of a large records database indicated. Compared with otherwise similar OA patients not taking… (MedPage Today) — People with knee osteoarthritis (OA) who used GLP-1 receptor agonists were less likely to Read More
AI helps accelerate breast cancer diagnosis for high-risk womenAI helps accelerate breast cancer diagnosis for high-risk women

Women with abnormal mammograms often have to wait for weeks to find out whether they have breast cancer. Now, researchers at UC San Francisco and UC Berkeley have found a way to help reduce the wait and the worry by using AI to quickly identify those who are most likely to have the disease. By triaging these patients, the AI-guided workflow takes women with abnormal scans through the diagnostic process—from imaging to evaluation and sometimes even biopsy—in a single day.
Omnipod Pod Recall; Afrezza OK’d for Kids 6 and Up; CVS to Cover Zepbound AgainOmnipod Pod Recall; Afrezza OK’d for Kids 6 and Up; CVS to Cover Zepbound Again

(MedPage Today) — Insulet initiated a voluntary device correction of certain Omnipod pods due to a manufacturing defect that causes insulin to leak rather than being fully delivered into the body, the FDA alerted. This action is separate from… (MedPage Today) — Insulet initiated a voluntary device correction of certain Omnipod pods due to Read More
GLP‑1 drugs like Ozempic show promise for more than weight loss, but what’s science vs. hype?GLP‑1 drugs like Ozempic show promise for more than weight loss, but what’s science vs. hype?

You’ve probably heard of Ozempic or Wegovy. These are the injectable drugs that have become household names for weight loss and diabetes. You’ve probably heard of Ozempic or Wegovy. These are the injectable drugs that have become household names for weight loss and diabetes.
More Data Support Trodelvy-Keytruda Combo in Triple-Negative Breast CancerMore Data Support Trodelvy-Keytruda Combo in Triple-Negative Breast Cancer

(MedPage Today) — CHICAGO — Sacituzumab govitecan (SG, Trodelvy) added to pembrolizumab (Keytruda) extended a surrogate measure of long-term clinical outcomes compared with chemotherapy plus pembrolizumab in patients with PD-L1-positive metastatic…