WHO Guideline on GLP-1 Therapies for Obesity in AdultsWHO Guideline on GLP-1 Therapies for Obesity in Adults
This Special Communication summarizes the WHO guideline on the management of obesity with GLP-1 therapies in adults and calls on nations to ensure equitable access to obesity prevention and management interventions. This Special Communication summarizes the WHO guideline on the management of obesity with GLP-1 therapies in adults and calls on nations to ensure equitable Read More
GLP-1 Pill Cut Heart Failure Events in Some Diabetes PatientsGLP-1 Pill Cut Heart Failure Events in Some Diabetes Patients
(MedPage Today) — Oral semaglutide (Rybelsus) protected against heart failure events in type 2 diabetes patients with a history of heart failure and either atherosclerotic cardiovascular disease, chronic kidney disease, or both, according to findings… (MedPage Today) — Oral semaglutide (Rybelsus) protected against heart failure events in type 2 diabetes patients with a history Read More
New genetic tools offer more accurate breast cancer prediction for women of African ancestryNew genetic tools offer more accurate breast cancer prediction for women of African ancestry
Despite major advances in genetic testing for breast cancer risk prediction, death rates remain disproportionately high among women of African ancestry. This is often due to a combination of factors, including failure of existing genetic models to accurately predict risk, higher rates of aggressive tumor subtypes, and later-stage diagnoses.
A portable ultrasound sensor may enable earlier detection of breast cancerA portable ultrasound sensor may enable earlier detection of breast cancer
For people who are at high risk of developing breast cancer, frequent screenings with ultrasound can help detect tumors early. MIT researchers have now developed a miniaturized ultrasound system that could make it easier for breast ultrasounds to be performed more often, either at home or at a doctor’s office. The new system consists of a small ultrasound probe attached to an acquisition and processing module that is a little larger than a smartphone. This system can be used on the go when connected to a laptop computer to reconstruct and view wide-angle 3D images in real time.
How early pregnancy impacts aging: Implications for breast-cancer riskHow early pregnancy impacts aging: Implications for breast-cancer risk
A new study by cell biologists at the University of California, Santa Cruz, suggests that an early first pregnancy may protect against breast cancer decades later by preventing age-related changes in breast cells that are linked to tumor formation. Using a mouse model designed to mimic human aging and reproductive history, researchers found that pregnancy fundamentally alters how mammary tissue ages—reducing the buildup of abnormal cells that have the ability to change their identity in a way that could seed cancer in later life.
Baseline Fatigue and Severe Toxic Effects in Patients With Cancer Receiving Systemic TherapyBaseline Fatigue and Severe Toxic Effects in Patients With Cancer Receiving Systemic Therapy
This cohort study using data from randomized clinical trials evaluates the association of baseline patient-reported fatigue and the risk of toxic effects during subsequent cancer treatment.
Unraveling the Complexity of Cancer-Related Cognitive Impairment in Breast CancerUnraveling the Complexity of Cancer-Related Cognitive Impairment in Breast Cancer
Cancer-related cognitive impairment (CRCI) is an important clinical problem that affects many patients with cancer and includes difficulties in memory, attention, processing speed, and executive function. Studies including patient-reported outcomes (PROs) suggest that 50% to 75% of patients receiving chemotherapy experience CRCI. These problems negatively affect daily functioning and can persist for many years. Given that CRCI exists in the short and long term, better understanding of the effect of disease and various treatment combinations on CRCI and whether there are differential effects in the magnitude of CRCI by treatment regimen and the contributions of host factors is needed.
Sleeve gastrectomy may produce greater and more durable weight loss than semaglutide in patients with obesitySleeve gastrectomy may produce greater and more durable weight loss than semaglutide in patients with obesity
1. Sleeve gastrectomy produces substantially greater and more durable weight loss than semaglutide over 12 months in patients with obesity. 2. Semaglutide is effective during treatment, but discontinuation frequently leads to clinically significant weight regain, highlighting the need for long-term treatment strategies. Evidence Rating Level: 2 (Good) In this prospective, non-randomized study, sleeve gastrectomy (SG) Read More
GLP-1 Warning Over Link to Fatal Events; DOJ Sues Med School; Genes and LongevityGLP-1 Warning Over Link to Fatal Events; DOJ Sues Med School; Genes and Longevity
(MedPage Today) — Note that some links may require registration or subscription. The United Kingdom’s Medicines and Healthcare Products Regulatory Agency strengthened its warnings on GLP-1 receptor agonists and dual GLP-1/GIP agonists to include… (MedPage Today) — Note that some links may require registration or subscription. The United Kingdom’s Medicines and Healthcare Products Regulatory Read More
AI-assisted mammograms cut risk of developing aggressive breast cancerAI-assisted mammograms cut risk of developing aggressive breast cancer
Interval cancers are aggressive tumours that grow during the interval after someone has been screened for cancer and before they are screened again, and AI seems to be able to identify them at an early stage