New GLP-1 pill orforglipron outperforms oral semaglutide in yearlong diabetes trial​New GLP-1 pill orforglipron outperforms oral semaglutide in yearlong diabetes trial 

A novel GLP-1 receptor agonist (RA) pill called orforglipron leads to a larger reduction in blood sugar levels after a year than the current available oral GLP-1 RA (semaglutide), finds a phase 3 randomized controlled trial published in The Lancet. Additionally, participants taking orforglipron had significantly greater reductions in body weight than those taking oral Read More

GLP-1 drugs combined with healthy lifestyle habits linked to reduced cardiovascular risk among diabetes patients​GLP-1 drugs combined with healthy lifestyle habits linked to reduced cardiovascular risk among diabetes patients 

Individuals living with type 2 diabetes (T2D) had a significantly lower risk of poor cardiovascular health when they used a GLP-1 receptor agonist (GLP-1 RA) in combination with adhering to healthy lifestyle habits, according to a new study led by researchers at Harvard T.H. Chan School of Public Health and the Department of Veterans Affairs Read More

GLP-1 drugs combined with healthy lifestyle habits linked with reduced cardiovascular risk among diabetes patients​GLP-1 drugs combined with healthy lifestyle habits linked with reduced cardiovascular risk among diabetes patients 

Home Chronic Diseases GLP-1 drugs combined with healthy lifestyle habits linked with reduced cardiovascular risk among diabetes patients By Maya Brownstein February 25, 2026 Hide caption Show caption aprott / iStock Jump to Section Share Post LinkedIn Facebook WhatsApp Email Copy link For immediate release: February 25, 2026 Boston, MA—Individuals living with type 2 diabetes Read More

Semaglutide Not Linked to Depression Symptoms in People With HIV​Semaglutide Not Linked to Depression Symptoms in People With HIV 

(MedPage Today) — DENVER — People with HIV didn’t have a significant rise in depressive symptoms after starting semaglutide (Ozempic, Wegovy, Rybelsus) for diabetes or weight loss, according to a nine-site observational study. After a median… ​ (MedPage Today) — DENVER — People with HIV didn’t have a significant rise in depressive symptoms after starting Read More

How an anti-obesity drug improves metabolism beyond weight loss​How an anti-obesity drug improves metabolism beyond weight loss 

Tirzepatide is one of the drugs that has revolutionized the treatment of obesity and other conditions such as diabetes in recent years. Despite its clinical success, its precise molecular and cellular mechanisms are still not fully understood. A study in mice shows that the drug has a direct impact on improving metabolism by activating brown adipose tissue, a type of fat specialized in energy expenditure.

STAT+: Pharmalittle: We’re reading about an FDA plan for ultra-rare drugs, Novo cutting GLP-1 drug prices, and more​STAT+: Pharmalittle: We’re reading about an FDA plan for ultra-rare drugs, Novo cutting GLP-1 drug prices, and more 

Rise and shine, everyone, another busy day is on the way. And it is getting off to a good start here on the Pharmalot campus, where we have clear blue skies and chilly breezes greeting us today. Who could ask for anything more? Actually, we could — it is time to reheat the tea kettle for Read More